From Bench To Bedside – Reducing The Heart Transplant Wait List Itaconate and Organ Preservation; You Just Can’t Escape the TCA Cycle
James DiNardo MD, Viviane Nasr MS, Susan Nicolson MS, Lindsey Loveland-Baptist MD
Original article
Lei I, Huang W, Noly PE, Naik S, Ghali M, Liu L, Pagani FD, El Ela AA, Pober JS, Pitt B, Platt JL, Cascalho M, Wang Z, Chen YE, Montensen TM, Tang PC. Metabolic Re-programming by immune-responsive gene 1 up-regulation improves donor heart preservation and function. Sci Transl Med. 2023 Feb 8;15(682):eade3782. doi: 10.1126/scitranslmed.ade3782. Epub 2023 Feb 8. PMID: 36753565
Improving heart preservation techniques then is a key to increasing the donor pool. Itaconate is a key autocrine regulatory component involved in the development and progression of inflammation and immunity. To understand its role, we need a review of the Kreb cycle. The Kreb cycle? Really? Well yes.
Rethinking and reimagining the magic of the pediatric anesthesiology fellowship experience Parts 1, 2, and 3
Myron Yaster MD, Justin L. Lockman MD, MSEd, and Aditee P. Ambardekar MD
Editorial
Cladis FP, Waisel D. Creating the Pediatric Anesthesiology Consultant: You Can't Have Your Cake and Eat It Too (Unless You Change the Recipe). Anesth Analg. 2023 Mar 1;136(3):434-436. PMID: 36806231
Original article
Ambardekar AP, Eriksen W, Ferschl MB, McNaull PP, Cohen IT, Greeley WJ, Lockman JL. A Consensus-Driven Approach to Redesigning Graduate Medical Education: The Pediatric Anesthesiology Delphi Study. Anesth Analg. 2023 Mar 1;136(3):437-445. PMID: 35777829fr
Original article
Ambardekar AP, Furukawa L, Eriksen W, McNaull PP, Greeley WJ, Lockman JL. A Consensus-Driven Revision of the Accreditation Council for Graduate Medical Education Case Log System: Pediatric Anesthesiology Fellowship Education. Anesth Analg. 2023 Mar 1;136(3):446-454. PMID: 35773224
Original article
Snell JJ, Lockman JL, Suresh S, Chatterjee D, Ellinas H, Walker KK, Gonzalez A, Edgar L, Ambardekar AP. Pediatric Anesthesiology Milestones 2.0: An Update, Rationale, and Plan Forward. Anesth Analg. 2023 Feb 13. doi: 10.1213/ANE.0000000000006381. Online ahead of print. PMID: 36780299
There is increasingly more expected of our fellows, their programs, and program directors by way of curricular and clinical experiences, in a year that is already too busy. How to improve the pediatric anesthesia fellowship is discussed in this 3 parter.
Reader response
Myron Yaster MD
From Dr. Joe Cravero, Anesthesiologist-in-Chief, Boston Children’s Hospital. Responding to the Association does not equal Causation post. There are many reasons why prolonged use of opioids occurs including abuse/misuse. Dr. Eshel A. Nir of the Rambam Health Care Campus, Israel discovered an important typo. Drs. Viviane Nasr and Susan Nicolson are MDs (not MS as printed). Dr. Lynne Maxwell provide a YouTube video on anaphylaxis. Dr. Elliot Krane, Stanford’s Lucille Packard Hospital on his first experience with ChatGPT.