Week in review February 27-March 3, 2023
Myron Yaster MD
Oliceridine...Oli what?
Myron Yaster MD
Original article
Pieter Simons, Rutger van der Schrier, Maarten van Lemmen, Simone Jansen, Kiki W K Kuijpers, Monique van Velzen, Elise Sarton, Todd Nicklas, Cathy Michalsky, Mark A Demitrack, Michael Fossler, Erik Olofsen, Marieke Niesters, Albert Dahan. Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic-Pharmacodynamic Comparison with Morphine. Anesthesiology 2023 Mar 1;138(3):249-263 PMID: 36538359
The search for the holy grail: mu agonist opioids that produce analgesia but minimal respiratory depression. Oliceridine is the first of the biased ligands that were designed do this…This study showed a 30% reduction in respiratory depression compared to morphine…enough to warrant the increased cost?
Finding a New Home: Approaching the Perioperative Care of Refugee Children
Samuel Percy MD and Debnath Chatterjee MD FAAP
Original Article
Kamath A, Gentry K, Dawson-Hahn E, Ross F, Chiem J, Patrao F, Greenberg S, Ibrahim A, Jimenez N. Tailoring the perioperative surgical home for children in refugee families. Int Anesthesiol Clin. 2023;61(1):1-7. PMID: 36409682
The authors describe a refugee perioperative surgical home model for refugee children requiring surgical care.
How to read a research paper
Joseph Cravero MD
Original article
von Ungern-Sternberg BS, Boda K, Chambers NA, Rebmann C, Johnson C, Sly PD, Habre W. Risk assessment for respiratory complications in paediatric anaesthesia: a prospective cohort study. Lancet. 2010 Sep 4;376(9743):773-83. PMID: 20816545
In a review of a classic paper, Dr. Cravero underscores the importance that clinical significance depends on absolute magnitude of the findings as well as the importance of the outcome that is being reported.
Navil Sethna MBchB, 2023 Robert M. Smith Award Winner
Gary Walco PhD
This year’s Robert M. Smith award winner is Navil Sethna MBchB of the Boston Children’s Hospital. Please register for the SPA annual meeting!
Original article
Navil F Sethna 1, Petra M Meier, David Zurakowski, Charles B Berde. Cutaneous sensory abnormalities in children and adolescents with complex regional pain syndromes. Pain. 2007 Sep;131(1-2):153-61. PMID: 17329025
Reader response
Elizabeth Malinzak MD Duke University on achieving equity for women in anesthesiology, From Anonymous describing the difficulties she faced and continues to face as a working mother. From Jerry Parness MD on the pressures women face in the workplace. From Nancy Glass MD on the trauma that ALL refugee have experienced and its implications perioperatively.