Week in review: August 9-13
Myron Yaster MD
Opioids and benzodiazepines in the NICU: Sophie’s Choice
Original Article
Puia-Dumitrescu M, Comstock BA, Li S, Heagerty PJ, Perez KM, Law JB, Wood TR, Gogcu S, Mayock DE, Juul SE, Consortium P: Assessment of 2-Year Neurodevelopmental Outcomes in Extremely Preterm Infants Receiving Opioids and Benzodiazepines. JAMA Netw Open 2021 Jul 1;4(7):e2115998. doi: 10.1001/jamanetworkopen.2021.15998 PMID: 34232302
Original Article
Christopher McPherson, Steven P Miller, Mohamed El-Dib, An N Massaro, Terrie E Inder. The influence of pain, agitation, and their management on the immature brain. Pediatr Res. 2020 Aug;88(2):168-175. PMID: 31896130
How or should we treat prolonged pain and sedation in the NICU (or PICU)? On the one hand, pain produces brain injury in the newborn (see Christopher McPherson et al. above), on the other hand, are opioids and benzodiazepines safe, particularly when used for prolonged periods of time?
Food allergy and Propofol
Original Article
Lisa Bagley, Anna Kordun, Sean Sinnott, Kimberly Lobo, Joseph Cravero. Food allergy history and reaction to propofol administration in a large pediatric population. Paediatr Anaesth. 2021 May;31(5):570-577. PMID: 33529424
Is it safe to use propofol in patients with known food allergy to eggs or soy?
Shark!
Original Article
David O Warner, Danqing Hu, Michael J Zaccariello, Darrell R Schroeder, Andrew C Hanson, Robert T Wilder, Juraj Sprung, Randall P Flick. Association Between Behavioral and Learning Outcomes and Single Exposures to Procedures Requiring General Anesthesia Before Age 3: Secondary Analysis of Data From Olmsted County, MN. Anesth Analg 2021 Jul 1;133(1):160-167 PMID: 32932391
Is a single anesthetic exposure in the very young associated with learning disabilities?
Doc “Moonlight” Graham: A special remembering the classics
One of the iconic characters in the movie Field of Dreams, Doc “Moonlight” Graham (“he could run faster than moonlight”), was a legendary community doctor, who before becoming a doctor played minor, and very briefly, major league baseball. His one and only paper, published in 1945 was the first to provide blood pressure norms in children